It has become increasingly clear that biological systems function as complex networks and, therefore, the network-based approach could be especially useful for the analysis of complex, multi-factorial traits and processes.
The network-based approach was previously used in our lab for the study of aging, longevity and age-related diseases (ARDs). We showed that longevity- and ARD-associated genes may act in a cooperative manner by forming protein-protein interaction (PPI) networks.[1-4]
The NetAge project was aimed at (i) extending our previous study towards developing a more adequate integrative network model, a miRNA-regulated PPI networks, and at (ii) building a publicly available database for networks associated with aging, longevity, ARDs, and related processes.
The database is available through the NetAge website, which provides the necessary bioinformatics tools for searching and browsing the networks, as well as showing network info and statistics. We hope that using NetAge, currently fragmented data on genes/proteins/miRNAs could be integrated and analyzed, thus contributing to a better understanding of the key players of aging, longevity. NetAge could also be important for the determination of potential drug targets.
1. Budovsky A, Abramovich A, Cohen R, Chalifa-Caspi V and Fraifeld V. Longevity network: Construction and implications.
Mech Ageing Dev 2007;128:117-124.
2. Budovsky A, Tacutu R, Yanai H, Abramovich A, Wolfson M, and Fraifeld V. Common gene signature of cancer and longevity.
Mech Ageing Dev 2009; (1-2):33-39.
3. Wolfson M, Budovsky A, Tacutu R, and Fraifeld V. The signaling hubs at the crossroad of longevity and age-related disease
networks. Int J Biochem Cell Biol 2009; 41(3):516-520.
4. Wolfson M, Tacutu R, Budovsky A, Aizenberg N, and Fraifeld V. MicroRNAs:Relevance to Aging and Age-related Diseases.
Open Longevity Science 2008; 10, 66-75, doi:10.2174/1876326X00802010066.
5. Tacutu R, Budovsky A, Fraifeld VE. The NetAge database: a compendium of networks for longevity, age-related diseases and
associated processes. Biogerontology 2010. [Epub ahead of print]
6. Tacutu R, Budovsky A, Wolfson M, Fraifeld V. MicroRNA-regulated protein-protein interaction networks: how could they help in
searching for pro-longevity targets? Rejuvenation Res 2010; 13(2), doi:10.1089/rej.2009.0980 (in press).